Scientific Reports of the National University of Life and Environmental Sciences of Ukraine

Biochemical effects of cold and hot-pressed thistle and linseed oils in rats with acute colitis

І. Kotlyar, H. Kuznіetsova, V. Rybalchenko
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Abstract

Inflammatory bowel disease (IBD) which includes ulcerative colitis (UC), is one of the most serious and currently unresolved problems of modern gastroenterology. The etiology of IBD is still not fully understood, the main causes are considered to be hereditary predisposition, allergic reactions, nutrition, etc. In this regard, it is important to prevent this pathology, in particular with the help of food supplements of natural origin, such as vegetable oils of flax and milk thistle, which are used in traditional medicine, including inflammatory diseases of the digestive system. Studies on their possible anti-inflammatory effects on the colonic mucosa and biochemical parameters of blood in ulcerative colitis have not been performed. Therefore, the aim is to evaluate the antioxidant effectiveness of vegetable oils (flaxseed and milk thistle, obtained by different methods of pressing) in a model of acute colitis in rats. Object of research: biochemical mechanisms of realization of influence of thistle and flaxseed oils of different methods of extraction at ulcerative colitis. The effects of linseed and milk thistle oils obtained by cold pressing (to 45°C) and hot pressing (to 95°C) on the development of acute colitis in rats, when administered with food, have been investigated. It was shown that the use of linseed oil both cold and hot-pressed under conditions of adding it to the feed in an amount of 10 % for 2 weeks prevents the development of inflammatory and destructive changes in the colon of rats with acute colitis and its negative consequences in the liver (for approaching to the normal values of serum markers of its functional activity). The data obtained may indicate that one of the mechanisms of implementation of the anti-inflammatory action of these substances is their ability to reduce oxidative stress - one of the main factors and promoters of inflammation

Keywords

flaxseed oil, milk thistle oil, acute colitis

Suggested citation
Kotlyar, І., Kuznіetsova, H., & Rybalchenko, V. (2021). Biochemical effects of cold and hot-pressed thistle and linseed oils in rats with acute colitis. Scientific Reports of the National University of Life and Environmental Sciences of Ukraine, 17(4),27-36. https://doi.org/dopovidi2021.04.003
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