The article is devoted to the establishment of age-old features of the neuro-humoral regulation of creative function in bitches. The experiment was carried out on 15 bitches (Canis familiaris) of the Bull Terrier breed (mature bitches with a middle age of 4.8; young - with a middle age of 1.4 years; old - with a middle age of 8.6 years). In the blood plasma of bitches over the course of a long period of time, follicle-stimulating hormone, luteinizing hormone, estradiol and progesterone were vibrated at different intervals. With doslizni, the young people have a bitch in the row of the Lutheanizuyuchi hormone (at 120–150 a doba of the Pisl splash LH-ղ²ᵪ = 0.46; p≤0.05), estradiol (for three that one doba for the day after the LH surge – ղ²ᵪ=0.45–0.62; P≤0.05–0.001), and progesterone (on the 23–30th day after the LH surge – ղ²ᵪ=0.43; P≤0.05). In older bitches, the eyelid rises to the level of follicle-stimulating hormone (on the 4th, 9th and 23–30th day after the LH surge - ղ²ᵪ=0.43–0.48; P≤0.05) and progesterone (on 9 the 35th–40th day after the LH surge – ղ²ᵪ=0.50-0.52; P≤0.05). The formation of influx is characterized by a greater level of state hormones in the blood of reproductive bitches of middle age compared to reproductive bitches of older and younger age. The difference in the level of state hormones in females of different ages will increase due to gravidity
dogs, eyelids, progesterone, luteinizing hormone, follicle-stimulating hormone, estradiol
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